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Fig. 10 | The Journal of Headache and Pain

Fig. 10

From: Dopamine receptor D2 regulates GLUA1-containing AMPA receptor trafficking and central sensitization through the PI3K signaling pathway in a male rat model of chronic migraine

Fig. 10

Regulation of the synaptic ultrastructure of neurons in the TNC in CM rats by DRD2 and the PI3K pathway. A representative electroscopic image of the synaptic ultrastructure in each group (Scale bar = 200 nm). B, C, and D Rats in the CM group had a thicker PSD(B), a higher synaptic interface curvature(C), and a wider synaptic cleft(D) than rats in the Sham group, and these changes were counteracted by both quinpirole and LY294002. One-way ANOVA with Dunnett’s post hoc test; n = 5/group; *P < 0.05, ***P < 0.001 vs. the Sham group; #P < 0.05, ##P < 0.01, ###P < 0.001 vs. the CM group

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