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Table 1 Basic features of demography and Headache

From: Gradually shifting clinical phenomics in migraine spectrum: a cross-sectional, multicenter study of 5438 patients

  MwoA MWA Total p value
Demographic Features     
Number (%)   4651 (85.53%) 787 (14.47%) 5438  
Gender* Female (%) 3747 (80.56%) 506 (64.29%) 4253 (78.21%) < 0.0001
Age* Mean ± SD (y) 39.33 ± 11.96 34.14 ± 13.67 38.58 ± 12.36 < 0.0001
≤ 18 (%) 3.83% 12.45% 5.08% < 0.0001
19 ~ 40 (%) 50.66% 56.54% 51.51%
> 40 (%) 45.52% 31.00% 43.42%
Age at Onset* Mean ± SD 28.72 ± 11.94 26.57 ± 13.57 28.40 ± 12.21 < 0.0001
≤ 18 (%) 22.14% 33.54% 23.83% < 0.0001
19 ~ 40 (%) 60.14% 46.85% 58.17%
> 40 (%) 15.59% 14.89% 15.49%
Headache Features
Migraine-like Headache Type* (%) 91.87% 86.40% 91.08% < 0.0001
Headache Intensity* VAS mean ± SD 7.13 ± 1.62 6.68 ± 1.86 7.06 ± 1.66 < 0.0001
mild (%) 1.18% 5.21% 1.77% < 0.0001
moderate (%) 32.79% 39.39% 33.74%
severe (%) 66.03% 55.40% 64.49%
Frequency Per Month* < 1 d/m (%) 8.54% 27.83% 11.33% < 0.0001
1 ~ 15 d/m (%) 70.61% 60.48% 69.14%
> 15 d/m (%) 20.86% 11.69% 19.53%
Aggravation by activity* none (%) 15.76% 23.51% 16.88% < 0.0001
occasionally (%) 8.56% 9.53% 8.70%
less than half (%) 7.33% 6.35% 7.19%
more than half (%) 68.35% 60.61% 67.23%
Headache Course* Mean ± SD (m) 126.85
± 115.73
90.82
± 104.57
121.62
± 114.87
< 0.0001
Headache Duration* Mean ± SD (h) 25.97
± 29.83
17.11
± 37.54
24.69
± 31.21
< 0.0001
Family History* (%) 46.91% 40.91% 46.05% 0.0003
Main Headache Area
Tempus* (%)   69.28% 61.50% 68.15% < 0.0001
Top (%)   39.91% 37.48% 39.55% 0.1989
Forehead (%)   23.35% 23.76% 23.41% 0.8010
Pars orbitalis (%) 12.17% 13.34% 12.34% 0.3551
Face (%)   0.67% 1.14% 0.74% 0.1475
Ear (%)   4.84% 4.19% 4.74% 0.4315
Occiput (%)   35.11% 32.66% 34.76% 0.1810
Neck (%)   2.37% 2.03% 2.32% 0.5669
Accompany Symptoms
Nausea* (%)   87.49% 78.02% 86.12% < 0.0001
Vomit (%)   59.49% 57.69% 59.23% 0.3406
Photophobia* (%) 61.97% 55.40% 61.02% 0.0005
Phonophobia* (%) 70.63% 62.77% 69.49% < 0.0001
Nasal Obstruction* (%) 1.68% 4.07% 2.02% < 0.0001
Lacrimation* (%) 2.56% 4.32% 2.81% 0.0057
Sweat* (%)   1.16% 5.59% 1.80% < 0.0001
Palpebral edema* (%) 0.65% 1.02% 0.70% 0.2473
Upset* (%)   6.49% 13.47% 7.50% < 0.0001
  1. Due to the low occurrence rate, some variables cannot be effectively statistically compared, including Jaw, Blepharoptosis, Myosis
  2. Headache intensity: mild (VSA 1 ~ 3), moderate (VSA 4 ~ 6), severe (VSA 7 ~ 10)
  3. Migraine-like Headache Type include throbbing headache, distending headache, bursting headache
  4. SD: standard deviation, h: hours, d: days, m: months, y: years, d/m: days/month, y: years old
  5. *p value < 0.05