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Table 1 Basic features of demography and Headache

From: Gradually shifting clinical phenomics in migraine spectrum: a cross-sectional, multicenter study of 5438 patients

 

MwoA

MWA

Total

p value

Demographic Features

    

Number (%)

 

4651 (85.53%)

787 (14.47%)

5438

 

Gender*

Female (%)

3747 (80.56%)

506 (64.29%)

4253 (78.21%)

< 0.0001

Age*

Mean ± SD (y)

39.33 ± 11.96

34.14 ± 13.67

38.58 ± 12.36

< 0.0001

≤ 18 (%)

3.83%

12.45%

5.08%

< 0.0001

19 ~ 40 (%)

50.66%

56.54%

51.51%

> 40 (%)

45.52%

31.00%

43.42%

Age at Onset*

Mean ± SD

28.72 ± 11.94

26.57 ± 13.57

28.40 ± 12.21

< 0.0001

≤ 18 (%)

22.14%

33.54%

23.83%

< 0.0001

19 ~ 40 (%)

60.14%

46.85%

58.17%

> 40 (%)

15.59%

14.89%

15.49%

Headache Features

Migraine-like Headache Type* (%)

91.87%

86.40%

91.08%

< 0.0001

Headache Intensity*

VAS mean ± SD

7.13 ± 1.62

6.68 ± 1.86

7.06 ± 1.66

< 0.0001

mild (%)

1.18%

5.21%

1.77%

< 0.0001

moderate (%)

32.79%

39.39%

33.74%

severe (%)

66.03%

55.40%

64.49%

Frequency Per Month*

< 1 d/m (%)

8.54%

27.83%

11.33%

< 0.0001

1 ~ 15 d/m (%)

70.61%

60.48%

69.14%

> 15 d/m (%)

20.86%

11.69%

19.53%

Aggravation by activity*

none (%)

15.76%

23.51%

16.88%

< 0.0001

occasionally (%)

8.56%

9.53%

8.70%

less than half (%)

7.33%

6.35%

7.19%

more than half (%)

68.35%

60.61%

67.23%

Headache Course*

Mean ± SD (m)

126.85

± 115.73

90.82

± 104.57

121.62

± 114.87

< 0.0001

Headache Duration*

Mean ± SD (h)

25.97

± 29.83

17.11

± 37.54

24.69

± 31.21

< 0.0001

Family History* (%)

46.91%

40.91%

46.05%

0.0003

Main Headache Area

Tempus* (%)

 

69.28%

61.50%

68.15%

< 0.0001

Top (%)

 

39.91%

37.48%

39.55%

0.1989

Forehead (%)

 

23.35%

23.76%

23.41%

0.8010

Pars orbitalis (%)

12.17%

13.34%

12.34%

0.3551

Face (%)

 

0.67%

1.14%

0.74%

0.1475

Ear (%)

 

4.84%

4.19%

4.74%

0.4315

Occiput (%)

 

35.11%

32.66%

34.76%

0.1810

Neck (%)

 

2.37%

2.03%

2.32%

0.5669

Accompany Symptoms

Nausea* (%)

 

87.49%

78.02%

86.12%

< 0.0001

Vomit (%)

 

59.49%

57.69%

59.23%

0.3406

Photophobia* (%)

61.97%

55.40%

61.02%

0.0005

Phonophobia* (%)

70.63%

62.77%

69.49%

< 0.0001

Nasal Obstruction* (%)

1.68%

4.07%

2.02%

< 0.0001

Lacrimation* (%)

2.56%

4.32%

2.81%

0.0057

Sweat* (%)

 

1.16%

5.59%

1.80%

< 0.0001

Palpebral edema* (%)

0.65%

1.02%

0.70%

0.2473

Upset* (%)

 

6.49%

13.47%

7.50%

< 0.0001

  1. Due to the low occurrence rate, some variables cannot be effectively statistically compared, including Jaw, Blepharoptosis, Myosis
  2. Headache intensity: mild (VSA 1 ~ 3), moderate (VSA 4 ~ 6), severe (VSA 7 ~ 10)
  3. Migraine-like Headache Type include throbbing headache, distending headache, bursting headache
  4. SD: standard deviation, h: hours, d: days, m: months, y: years, d/m: days/month, y: years old
  5. *p value < 0.05