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Table 2 Univariate analyses & multiple logistic regression comparing baseline characteristics between responders and non-responders

From: Efficacy of erenumab and factors predicting response after 3 months in treatment resistant chronic migraine: a clinical service evaluation

Univariate Analyses Multiple logistic regression
Variable Responders (n = 68) Non-responders (n = 30) Difference (95% CI) p-value Odds ratio
(95% CI)
p-value
Age (mean ± SEM) 44.8 ± 1.56 44.1 ± 2.16 -0.62
(-6.07 – 4.84)
p = 0.8230* 1.00
(0.96 to 1.04)
p = 0.8742
Gender (n [%] female) 57 [83.8%] 26 [86.7%] OR 0.79 (0.26 – 2.66) p > 0.9999† 1.07
(0.29 to 4.55)
p = 0.9240
Baseline headache days (median [IQR]) 27 [22–28] 28 [28–28] 1
(0 – 2)
p = 0.0006 1.03
(0.77 to 1.36)
p = 0.8058
Number of previously tried treatments (median [IQR]) 7 [6.25–8] 7 [6-8] 0
(-1 – 0)
p = 0.3922‡ 1.29
(0.90 to 1.87)
p = 0.1701
Any medication overuse at baseline (n [%])** 35/63 [55.6%] 13/28
[46.4%]
OR 1.44 (0.56 – 3.40) p = 0.50† 1.41
(0.52 – 3.89)
p = 0.5048
Daily headache at baseline (n [%]) 33 [48.5%] 26 [86.7%] OR 0.15 (0.05 – 0.44) p = 0.0003 0.11
(0.01 – 0.73)
p = 0.0395
  1. * means compared with unpaired t-test
  2. medians compared with Mann–Whitney U-test
  3. contingency assessed with Fisher’s exact test
  4. OR Odds Ratio, CI Confidence interval, IQR Interquartile range