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Table 5 Multi-state model for the migraine preventive treatment: risk of discontinuation and analyzed covariates

From: Persistence, use of resources and costs in patients under migraine preventive treatment: the PERSEC study

  From the 1st line From the 2nd line From the 3rd or higher
HR SD P HR SD P HR SD P
Agea 5.06  < 0.001  < 0.001 5.10  < 0.001  < 0.001 5.09 0.01 0.237
Gender 0.98 0.03 0.526 0.87 0.19 0.455 1.09 0.55 0.882
CCI 1.01 0.01 0.516 0.95 0.09 0.582 1.01 0.28 0.96
Time since diagnosis 0.99 0.01 0.048 0.97 0.04 0.432 1.04 0.11 0.730
Discontinuation (vs. 1st line) n/a 0.24 0.35  < 0.001 0.21 0.98 0.110
  1. CCI Charlson Comorbidity Index, HR hazard ratio, n/a not applicable, SD standard deviation, P p-value
  2. a5-year HR