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Table 4 Annual healthcare and non-healthcare costs associated with migraine patient management and preventive treatment persistence

From: Persistence, use of resources and costs in patients under migraine preventive treatment: the PERSEC study

 

Non-persistent patients

N = 5414 (69.4%)

Persistent patients

N = 2390 (30.6%)

Difference (Persistent – Non-persistent)

N = 7866

Health servicesa, € patient-year

 Primary Care visits,

  Mean (SD)

278.1 (204.1)

208.9 (200.9)

-69.2

  95% CI

  

(-79.0; -59.4)

 Specialist visits

  Mean (SD)

199.4 (104.4)

100.7 (87.8)

-98.7

  95% CI

  

(-103.5; -93.9)

 A&E admissions

  Mean (SD)

156.9 (259.2)

56.2 (135.3)

-100.7

  95% CI

  

(-111.7; -89.7)

 Hospital stays

  Mean (SD)

76.2 (681.4)

59.8 (628.0)

-16.5

  95% CI

  

(-48.5; 15.6)

Medical testsb, € patient-year

 Laboratory tests

  Mean (SD)

45.2 (38.7)

23.6 (34.4)

-21.6

  95% CI

  

(-23.4; -19.8)

 Conventional radiology

  Mean (SD)

30.2 (41.4)

28.0 (40.2)

-2.2

  95% CI

  

(-4.2; -0.2)

 CT scan

  Mean (SD)

6.4 (26.0)

4.9 (22.5)

-1.5

  95% CI

  

(-2.7; -0.3)

 MRI

  Mean (SD)

21.7 (77.0)

19.5 (72.4)

-2.2

  95% CI

  

(-5.9; 1.4)

 Other tests

  Mean (SD)

55.9 (57.0)

48.4 (50.4)

-7.5

  95% CI

  

(-10.2; -4.9)

Medicationc, € patient-year

 Symptomatic medication

  Mean (SD)

254.8 (769.4)

257.7 (933.3)

2.9

  95% CI

  

(-36.7; 42.5)

 Preventive medication

  Mean (SD)

155.9 (368.1)

152.3 (373.6)

-3.5

  95% CI

  

(-21.3; 14.3)

 Concomitant medication

  Mean (SD)

162.0 (389.4)

141.5 (437.9)

-20.5

  95% CI

  

(-40.0; -1.0)

Total healthcare direct costs, € patient-year

 Mean (SD)

1,476.8 (1,472.9)

1,127.1 (1,521.4)

-349.8

 95% CI

  

(-421.4; -278.1)

Non-healthcare indirect costs, € patient-yeard

 Mean (SD)

1,490.0 (3,930.0)

1,217.7 (3,786.4)

-272.3

 95% CI

  

(-459.4; -85.2)

Total costs, € patient-year

 Mean (SD)

2,966.8 (4,352.6)

2,344.8 (4,189.1)

-622.1

 95% CI

  

(-829.2; -414.9)

Adjusted costs, € patient-yeare

 Mean

2,929.0

2,346.0

-583.0

 (95% CI)

(2,784.0;3,073.0)

(2,130.0;2,562.0)

(-708.0; -458.0)

  1. CCI Charlson Comorbidity Index, CI confidence interval, CT computed tomography, MRI magnetic resonance imaging, SD standard deviation, VAT Value-Added Tax
  2. aUnit costs as per the 2019 analytical accounts: Primary Care visit: €23.2; specialist visit (Neurology, Internal Medicine and Anaesthesiology only): €92.5; A&E admission: €117.5; overnight hospital stay: €480.9; pain clinic visit: €185.0
  3. bUnit costs as per the 2019 analytical accounts: laboratory tests: €32.3; conventional radiology: €28.5; CT scan: €96.0; MRI: €177.0; other diagnostic tests: €47.1
  4. cUnit costs including VAT at the time of prescription
  5. dUnworked day cost: €101.21
  6. eANCOVA model, least square means corrected for the following covariates: gender, age, CCI and time since diagnosis
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The Journal of Headache and Pain

ISSN: 1129-2377

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