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Fig. 1 | The Journal of Headache and Pain

Fig. 1

From: P2X7R/NLRP3 signaling pathway-mediated pyroptosis and neuroinflammation contributed to cognitive impairment in a mouse model of migraine

Fig. 1

The experimental protocol of the study. (a) Schematic timeline diagram of drug treatment and behavioral assessment in mice. (b) Details of the dosing regimen for each group of mice. IS, 20μL/day for 4 days, dural injection; PBS, 20μL/day for 4 days, dural injection; BBG, a specific P2X7R antagonist, 50 mg/kg/day for 4 days, intraperitoneal injection; VEH, 0.9% saline, the same volume as BBG, intraperitoneal injection. Abbreviations: DS, dural stimulation; i.p., intraperitoneal injection; VFT, von Frey’s test; IS, inflammatory soup; PBS, phosphate buffer saline; BBG, brilliant blue G; VEH, vehicle

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