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Table 3 Levels of tryptophan metabolite in feces (mean ± SD)

From: Repeated inflammatory dural stimulation-induced cephalic allodynia causes alteration of gut microbial composition in rats

 

IS group

VEH group

p-value

L-TRP (µg/g)

5.83 ± 2.36

7.77 ± 3.27

0.27

5-HT (µg/g)

1.10 ± 0.79

0.62 ± 0.33

0.21

NAS (µg/g)

0.13 ± 0.13

0.10 ± 0.03

0.55

5-HIAA (µg/g)

0.32 ± 0.20

0.32 ± 0.14

0.99

L-KYN (ng/g)

34.1 ± 12.5

40.3 ± 19.5

0.53

KYNA (µg/g)

0.50 ± 0.71

0.24 ± 0.21

0.09

XA (µg/g)

0.06 ± 0.03

0.15 ± 0.10

0.09

PiA (µg/g)

3.82 ± 2.72

4.36 ± 3.21

0.76

IAM (ng/g)

32.5 ± 8.83

12.8 ± 2.07

0.02*

IAA (µg/g)

0.81 ± 0.48

1.19 ± 0.98

0.42

IAld (µg/g)

0.29 ± 0.12

0.38 ± 0.16

0.33

TRM (µg/g)

0.81 ± 0.43

1.16 ± 0.38

0.17

IEt (µg/g)

0.12 ± 0.05

0.06 ± 0.03

0.03*

ILA (ng/g)

24.2 ± 17.8

39.5 ± 53.2

0.70

IA (ng/g)

32.4 ± 15.1

29.9 ± 8.63

0.73

IPA (µg/g)

0.54 ± 0.37

0.60 ± 0.28

0.75

  1. L-TRP L-tryptophan, 5-HT serotonin, NAS N-acetylserotonin, 5-HIAA 5-hydroxyindoleacetic acid, L-KYN L-kynurenine, KYNA kynurenic acid, XA xanthurenic acid, PiA picolinic acid, IAM indole-3-acetamide, IAA β-indole-3-acetic acid, IAld indole-3-aldehyde, TRM tryptamine, IEt tryptophol (indoleethanol), ILA indole-3-lactic acid, IA indole-3-β-acrylic acid, IPA indole-3-propionic acid