Fig. 2

Effects of repeated dural IS infusions on behavioral characteristics. A Comparisons of periorbital mechanical threshold among groups. B Comparisons of immobility time among groups. C Comparisons of the moving distance among groups. D Representative trajectory of each group on day 5. Data are presented as the mean ± SEM (n = 8; *P < 0.05, **P < 0.01, compared with the VEH group; ^P < 0.05, ^^P < 0.01, compared with the TO-VEH group; ^#P < 0.05, ^##P < 0.01, compared with the TO-IS group)