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Table 4 Univariate analysis of the correlation between vasoactive peptides and clinical characteristics

From: CGRP and PACAP-38 play an important role in diagnosing pediatric migraine

Characteristics

PACAP-38 (ng/ml)

P-value

CGRP (pg/ml)

P-value

Age (years)

 

0.503

 

0.573

  0–6

40.65 ± 7.74

 

102.44 ± 13.35

 

  6–12

40.82 ± 4.79

 

106.25 ± 14.10

 

  12–18

42.33 ± 5.05

 

106.82 ± 11.48

 

Gender

 

0.277

 

0.579

  Man

42.07 ± 4.71

 

106.65 ± 10.71

 

  Women

40.69 ± 6.06

 

104.98 ± 14.79

 

Course (months)

 

0.017*

 

0.582

  0–6

42.33 ± 5.04

 

106.82 ± 11.48

 

  6–12

40.38 ± 5.43

 

104.11 ± 13.57

 

  12–18

42.27 ± 4.33

 

111.38 ± 11.86

 

  18–24

33.03 ± 3.79

 

104.43 ± 10.56

 

  > 24

46.23 ± 3.42

 

108.74 ± 7.39

 

Duration attacks (hours)

 

0.004**

 

0.063

  0–2

41.82 ± 4.81

 

105.91 ± 13.04

 

  2–4

39.32 ± 5.46

 

102.46 ± 13.25

 

  4–6

43.43 ± 3.22

 

109.08 ± 5.93

 

  > 6

42.31 ± 5.50

 

105.16 ± 9.13

 

VAS score

 

0.092

 

0.726

  0–3

46.18 ± 3.75

 

110.87 ± 7.39

 

  4–6

41.93 ± 6.82

 

105.15 ± 17.25

 

  7–10

40.75 ± 5.23

 

105.94 ± 10.84

 

Frequency (times/month)

 

0.005**

 

0.011*

  0–15

45.04 ± 3.82

 

113.63 ± 14.16

 

  15–30

42.07 ± 4.87

 

107.89 ± 12.44

 

  30–60

40.36 ± 4.18

 

100.42 ± 11.23

 

Aura

 Visual aura

40.10 ± 6.84

0.266

108.32 ± 13.36

0.322

 Sensory aura

41.01 ± 4.84

0.786

103.29 ± 13.34

0.362

 Motor aura

38.90 ± 5.13

0.222

102.56 ± 15.90

0.500

Concomitant symptoms

 Nausea

40.94 ± 6.23

0.552

109.28 ± 12.55

0.020*

 Vomiting

43.49 ± 4.68

0.019*

107.57 ± 13.42

0.411

 Photophobia

43.03 ± 7.57

0.133

107.75 ± 15.72

0.459

 Phonophobia

42.04 ± 8.75

0.625

104.04 ± 15.12

0.624

 Dizziness

40.97 ± 5.98

0.671

107.42 ± 13.38

0.396

 Ophthalmalgia

41.51 ± 4.50

0.904

109.30 ± 5.73

0.330

 Abdominal pain

39.14 ± 6.70

0.100

102.85 ± 13.17

0.360

Pain site

 Unilateral temporal

41.85 ± 4.93

0.611

105.91 ± 11.35

0.948

 Bilateral temporal

42.41 ± 3.94

0.437

112.43 ± 12.64

0.041*

 Frontal

40.49 ± 6.28

0.312

103.97 ± 13.56

0.365

 Parietal

40.03 ± 4.42

0.177

104.48 ± 11.86

0.578

 Occipital

42.18 ± 5.03

0.608

107.20 ± 10.26

0.708

  1. *p < 0.05; **p < 0.01
  2. Clinical Characteristics with P less than 0.2 were included in the multivariate analysis of the correlation between vasoactive peptides and clinical characteristics.