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Table 4 Mean monthly number of medication prescriptions among persistent (≥ 6 months) patients with a defined dose (n = 746)

From: A real-world study of acute and preventive medication use, adherence, and persistence in patients prescribed fremanezumab in the United States

 

Baseline

Months post-initiation

1

2

3

4

5

6

Acute medication, mean (SD)

1.89 (2.86)

0.57 (0.91)a

0.22 (0.69)a

0.25 (0.61)a

0.31 (1.04)a

0.24 (0.67)a

0.25 (0.74)a

 Triptans

0.68 (1.12)

0.30 (0.60)a

0.08 (0.36)a

0.09 (0.35)a

0.11 (0.37)a

0.10 (0.41)a

0.08 (0.29)a

 Ergot alkaloids

0.04 (0.41)

0.01 (0.10)c

0.01 (0.14)b

0.004 (0.08)b

0.01 (0.10)b

0.01 (0.10)c

0.01 (0.07)b

 NSAID analgesics

0.39 (0.95)

0.08 (0.33)a

0.03 (0.18)a

0.04 (0.21)a

0.05 (0.25)a

0.03 (0.17)a

0.05 (0.32)a

 Opioid analgesics

0.56 (2.06)

0.10 (0.49)a

0.07 (0.34)a

0.07 (0.31)a

0.08 (0.58)a

0.06 (0.39)a

0.08 (0.42)a

Preventive nonspecific migraine medication, mean (SD)

2.22 (2.62)

0.58 (0.94)a

0.30 (0.66)a

0.34 (0.77)a

0.33 (0.78)a

0.27 (0.62)a

0.31 (0.70)a

 Anticonvulsants/antiepileptics

0.81 (1.36)

0.25 (0.56)a

0.10 (0.35)a

0.11 (0.41)a

0.15 (0.57)a

0.10 (0.39)a

0.12 (0.40)a

 Antihypertensive

0.34 (0.82)

0.10 (0.35)a

0.07 (0.30)a

0.06 (0.28)a

0.07 (0.30)a

0.05 (0.27)a

0.06 (0.29)a

 Antidepressants

0.62 (1.21)

0.12 (0.37)a

0.07 (0.30)a

0.09 (0.39)a

0.06 (0.27)a

0.06 (0.27)a

0.07 (0.29)a

 Botox

0.14 (0.52)

0.03 (0.18)a

0.02 (0.14)a

0.03 (0.20)a

0.01 (0.10)a

0.01 (0.11)a

0.02 (0.18)a

  1. SD standard deviation, NSAID nonsteroidal anti-inflammatory drug
  2. P values calculated via paired t-test against baseline mean
  3. aP < 0.001
  4. bP = 0.005
  5. cP = 0.023