|  | Defined dose |  | |
---|---|---|---|---|
 | Overall (N = 987) | Quarterly (n = 186) | Monthly (n = 801) | P valuea (quarterly vs monthly) |
Age, years, mean (SD) | 46.8 (12.8) | 47.1 (13.6) | 46.7 (12.6) | 0.697 |
Age, years, n (%) | ||||
 18–40 | 314 (31.8) | 59 (31.7) | 255 (31.8) | 0.976 |
 41–64 | 595 (60.3) | 104 (55.9) | 491 (61.3) | 0.176 |
  ≥ 65 | 78 (7.9) | 23 (12.4) | 55 (6.9) | 0.012 |
Sex, n (%) | ||||
 Female | 842 (85.3) | 161 (86.6) | 681 (85.0) | 0.593 |
 Male | 145 (14.7) | 25 (13.4) | 120 (15.0) | 0.593 |
Migraine diagnosis, n (%) | ||||
 EM | 594 (60.2) | 123 (66.1) | 471 (58.8) |  |
 CM | 393 (39.8) | 63 (33.9) | 330 (41.2) |  |
Time from diagnosis to initial treatment, months, mean (SD) | 29.2 (20.8) | 27.1 (21.1) | 29.6 (20.8) | 0.141 |
Provider specialty, n (%) | ||||
 Neurology | 526 (53.3) | 82 (44.0) | 444 (55.4) | 0.005 |
 Family medicine | 122 (12.4) | 30 (16.1) | 92 (11.5) | 0.083 |
 Psychiatry | 93 (9.4) | 32 (17.2) | 61 (7.6) |  < 0.001 |
 Specialist/nurse/PA | 24 (2.4) | 5 (2.7) | 19 (2.4) | 0.801 |
 Physical medicine | 19 (1.9) | 0 | 19 (2.4) | N/A |
 Anesthesiology/pain management | 13 (1.3) | 8 (4.3) | 5 (0.6) |  < 0.001 |
 Headache orofacial pain | 15 (1.5) | 0 | 15 (1.9) | N/A |
 Otherb | 175 (17.7) | 29 (15.6) | 146 (18.2) | 0.396 |
Quan-Charlson comorbidity index score, mean (SD) | 0.30 (0.84) | 0.32 (0.99) | 0.29 (0.80) | 0.684 |
 0, n (%) | 813 (82.4) | 154 (82.8) | 659 (82.3) | 0.688 |
 1–3 | 161 (16.3) | 28 (15.1) | 133 (16.6) | 0.764 |
 4–6 | 10 (1.0) | 3 (1.6) | 7 (0.9) | 0.240 |
  > 6 | 3 (0.3) | 1 (0.5) | 2 (0.2) | 0.113 |
Common (> 10%) migraine-specific comorbidities, n (%) | ||||
 Anxiety (including GAD) | 152 (15.4) | 30 (16.1) | 122 (15.2) | 0.760 |
 Depression (including MDD) | 143 (14.5) | 32 (17.2) | 111 (13.9) | 0.243 |
 High cholesterol | 118 (12.0) | 23 (12.4) | 95 (11.9) | 0.848 |
 Back pain | 117 (11.9) | 20 (10.8) | 97 (12.1) | 0.606 |
 Hypertension | 115 (11.7) | 24 (12.9) | 91 (11.4) | 0.555 |
 Neck pain | 102 (10.3) | 25 (13.4) | 77 (9.6) | 0.122 |
 Insomnia | 100 (10.1) | 26 (14.0) | 74 (9.2) | 0.054 |