Genome-wide analysis identified novel susceptible genes of restless legs syndrome in migraineurs

Table 1 Association results for restless legs syndrome in patients with migraine

SNP	Gene	Chr	Position	Risk allele	stage	RAF		OR (95%CI)		P value	The P value adjusted
SNP	Gene	Chr	Position	Risk allele	stage	Case	Control	OR (95%CI)		(trend)
rs79823654	CCDC141	2	179,839,018	A	1	0.130	0.053	2.740	(1.715–4.377)	1.05 × 10^–5	2.51 × 10^–5
					2	0.101	0.061	1.642	(1.084–2.486)	0.017	0.0179
					Joint	0.113	0.057	2.046	(1.501–2.788)	3.27 × 10^–6	5.81 × 10^–6
					R1	0.113	0.066	1.857	(1.344–2.565)	2.75 × 10^–4	1.76 × 10^–4
rs6021854	VSTM2L	20	36,545,927	A	1	0.252	0.116	2.447	(1.738–3.446)	8.63 × 10^–8	4.69 × 10^–7
					2	0.182	0.136	1.421	(1.021–1.977)	0.036	0.03598
					Joint	0.213	0.127	1.838	(1.451–2.328)	2.73 × 10^–7	4.63 × 10^–7
					R1	0.213	0.154	1.504	(1.175–1.925)	9.73 × 10^–4	1.19 × 10^–3

SNP single nucleotide polymorphism, Chr chromosome, OR odds ratio for risk allele, CI confidence interval, PC principal component; Stage 1 (GWAS) included 115 cases and 635 controls; Stage 2 (replication stage) included 149 cases and 748 controls; Joint: Combining stage 1 and 2; R1: combined cases (264 migraineurs with RLS) vs. 1,053 normal controls
P value is derived from trend test, the P value adjusted is derived from the logistic regression adjusted with age and sex; Risk allele, allele with higher frequency in cases compared to controls. All genomic information is from human genome build hg19

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