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Fig. 1 | The Journal of Headache and Pain

Fig. 1

From: Calcitonin gene-related peptide receptor antagonist BIBN4096BS regulates synaptic transmission in the vestibular nucleus and improves vestibular function via PKC/ERK/CREB pathway in an experimental chronic migraine rat model

Fig. 1

Recurrent NTG administration induced mechanical allodynia, thermal hyperalgesia, and vestibular dysfunction. A. Timeline of behavior studies’ protocol. B-G. Basal and post-treatment responses of periorbital (B, C) and hind paw (D, E) mechanical and thermal thresholds (F, G) after NTG injection. Balance beam walk (H) and geotaxis reflex test (I) in each group. n = 6/group. Results are mean ± SD. Two-way analysis of variance (ANOVA), Bonferroni; *p < 0.05 compared with saline group, #p < 0.05 compared with before NTG injection

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The Journal of Headache and Pain

ISSN: 1129-2377

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