Fig. 1

Effects of ACEA on capsaicin-induced CGRP release from dura and TG. Application of 140 nM ACEA caused a significant increase in CGRP release from the dura (n = 8). 100 nM capsaicin caused a significant increase in CGRP release, which was not attenuated by the presence of ACEA. B Graphical illustration of the sample pairing. C Application of 140 nM ACEA had no effect on the CGRP release from the TG per se, nor on the release induced by 100 nM capsaicin (n = 12). D Graphical illustration of the sample pairing. B = baseline. Timeline in minutes are added on the lower panel. Data are shown as mean ± SEM or their individual data points with pairing, and with p values obtained with Student’s T-test being depicted in the graph (* = p < 0.05). For reference 100 pg/ml equals 26.4 pmol/l