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Fig. 7 | The Journal of Headache and Pain

Fig. 7

From: Sphingosine-1 phosphate receptor 1 contributes to central sensitization in recurrent nitroglycerin-induced chronic migraine model

Fig. 7

Inhibition of STAT3 activity could suppress the expression level of CGRP and c-fos. A, B Representative immunofluorescence staining images (A) and quantitative analysis of CGRP in the TCC area among the Saline, NTG, NTG + VEH and NTG + AG490 groups (B). Repeated daily injection of AG490 inhibited the increased immunoreactivity of CGRP induced by chronic NTG administration. n = 4/group; *p < 0.05 vs. Saline group; ###p < 0.001 vs. NTG group. Scale bars = 50 μm. C, D Quantitative analysis of c-fos immunoreactive (ir) cells indicated daily administration of AG490 decreased c-fos ir cells. n = 4/group; ***p < 0.001 compared with the Saline group; ###p < 0.001 for the NTG + AG490 group compared with the NTG group. Scale bars = 50 μm

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