Skip to main content
Fig. 4 | The Journal of Headache and Pain

Fig. 4

From: Sphingosine-1 phosphate receptor 1 contributes to central sensitization in recurrent nitroglycerin-induced chronic migraine model

Fig. 4

Blocking S1PR1 signaling suppressed NTG-induced microglia activation in the TCC area. A Representative immunofluorescence images of Iba1 in the TCC for the Saline, NTG, NTG + VEH and NTG + W146 group under an 10 × objective lens. B-C Western blots showed the changes in iNOS protein levels among the Saline, NTG, NTG + VEH and NTG + W146 group. These results indicated daily administration of W146 decreased the expression of iNOS. n = 6 per group; *p < 0.05 compared with the Saline group; ###p < 0.001 compared with the NTG group. D Quantification of Iba1-positive cells. These results indicated daily administration of W146 decreased Iba1 ir cells. n = 3 per group; ***p < 0.001 compared with the Saline group; ###p < 0.001 for the NTG + W146 group compared with the NTG group

Back to article page

The Journal of Headache and Pain

ISSN: 1129-2377

Contact us