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Fig. 1 | The Journal of Headache and Pain

Fig. 1

From: Sphingosine-1 phosphate receptor 1 contributes to central sensitization in recurrent nitroglycerin-induced chronic migraine model

Fig. 1

Upregulation of S1PR1 expression at mRNA and protein levels after chronic NTG injection. A Timeline of NTG or saline administration and behavioral testing. B-D Compared with the Saline group, the mechanical pain thresholds of periorbital in the NTG group gradually decreased from fifth day (n = 8/group, *p < 0.05, vs Saline); the mechanical and thermal pain thresholds of hindpaw in the NTG group gradually decreased from third day (n = 8/group, **p < 0.01, vs Saline); *p < 0.05, **p < 0.01 and ***p < 0.001 compared with the Saline group. E, F The expression of S1PR1 at protein level increased in the TCC following NTG injection for 9 days (n = 6/group, *p < 0.05, vs Saline). G The mRNA relative expression of S1PR1 increased in the NTG (9d) group compare with the Saline group (n = 6/group, **p < 0.01, vs Saline)

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