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Fig. 4 | The Journal of Headache and Pain

Fig. 4

From: Lasmiditan and 5-Hydroxytryptamine in the rat trigeminal system; expression, release and interactions with 5-HT1 receptors

Fig. 4

Double staining CGRP receptor element RAMP1 and 5-HT1B/D/F receptors. RAMP1 was expressed in larger neurons cell bodies (Arrowheads) and Aδ-fibres (Arrows). Several 5-HT1 receptor positive neurons did not display RAMP1-ir (Asterixes). A 5-HT1B receptor ir co-localized with RAMP1 in larger neurons (Arrowhead). A weak ir for the 5-HT1B receptor could be detected in the RAMP1 labelled Aδ-fibres (Arrows). B 5-HT1D receptor ir co-localized with RAMP1 in Aδ-fibres (Arrow) and larger neurons (Arrowhead). C 5-HT1F receptors were not expressed in observed RAMP1 positive Aδ-fibres (Arrow). Weakly positive 5-HT1F neurons could be observed in neuron cell bodies positive to RAMP1 (Arrowhead)

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The Journal of Headache and Pain

ISSN: 1129-2377

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