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Fig. 11 | The Journal of Headache and Pain

Fig. 11

From: Lasmiditan and 5-Hydroxytryptamine in the rat trigeminal system; expression, release and interactions with 5-HT1 receptors

Fig. 11

Stimulated release of 5-HT and CGRP in TG and dura mater. A The addition of 60 mM KCl (K+) caused no 5-HT release from the dura (n = 6) or soma-poor TG (n = 5), but a significant release was seen from the soma-rich TG (n = 6). B The addition of 100 nM capsaicin caused no 5-HT release from the dura (n = 7), soma-poor (n = 5) or soma right TG (n = 6). In contrast a significant reduction in 5-HT was observed for both the soma-poor and soma-rich TG. For all the samples CGRP content was also measured and used for the correlation analysis. Data are shown as mean ± SEM or their individual data points with pairing, and with p values obtained with Student’s T-test being depicted in the graph

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