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Fig. 10 | The Journal of Headache and Pain

Fig. 10

From: Lasmiditan and 5-Hydroxytryptamine in the rat trigeminal system; expression, release and interactions with 5-HT1 receptors

Fig. 10

The involvement of 5-HT1B and 5-HT1D receptors on the inhibitory effect of Lasmiditan. Ten minutes before the addition of 30 μM Lasmiditan: (A) 100 nM (n=4), (B) 300 nM (n=6) or (C) 1 μM (n=5) of GR127935, a 5-HT1B/5-HT1D blocker was added to the dura which subsequently stimulated with 60 mM KCl (K+). Similarly, 10 minutes before the addition of 30 μM Lasmiditan, and before the addition of 60 mM KCl (K+) (D) 100 nM (n = 5), (E) 300 nM (n = 16) or (F) 1 μM (n = 6) of GR127935, was added to the TGs which subsequently stimulated with 60 mM KCl (K+). The reduction in CGRP release caused by Lasmiditan could be inhibited by 300 nM GR127935 in the TG (p = 0.014), with a tendency observed in the dura at the same concentration. Data are shown as mean ± SEM with * p>0.05, from the paired Student’s T-test being depicted in the graph

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