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Table 3 PI-MBS and PGIC ratings at Week 12 in eptinezumab-treated ≥ 75% and ≥ 50–< 75% migraine responders (PROMISE-2; eptinezumab pooled)

From: Patient-reported outcomes, health-related quality of life, and acute medication use in patients with a ≥ 75% response to eptinezumab: subgroup pooled analysis of the PROMISE trials

 

PI-MBS

PGIC

≥ 50–< 75%

≥ 75%

≥ 50–< 75%

≥ 75%

n

200

208

200

207

Very much improved

33 (16.5%)

87 (41.8%)

40 (20.0%)

75 (36.2%)

Much improved

101 (50.5%)

90 (43.3%)

99 (49.5%)

103 (49.8%)

Minimally improved

46 (23.0%)

21 (10.1%)

40 (20.0%)

16 (7.7%)

No change

14 (7.0%)

5 (2.4%)

17 (8.5%)

10 (4.8%)

Minimally worse

5 (2.5%)

5 (2.4%)

2 (1.0%)

3 (1.4%)

Much worse

1 (0.5%)

0

2 (1.0%)

0

  1. A ≥ 75% or ≥ 50–< 75% migraine responder was defined as a patient who achieved a ≥ 75% or ≥ 50–< 75% reduction in mean monthly migraine days over Weeks 1–12. PGIC, Patient Global Impression of Change; PI-MBS, patient-identified most bothersome symptom