Table 1 Systemic physiology during CSD recording in different nVNS paradigms
| Â | n | pH | pCO2 (mmHg) | pO2 (mmHg) | BP (mmHg) |
|---|---|---|---|---|---|
Amplitude-response | Â | Â | Â | Â | Â |
Sham stimulation | 6 | 7.41\(\pm\)0.01 | 36\(\pm\)2 | 100\(\pm 3\) | 94\(\pm 3\) |
Low intensity nVNS | 6 | 7.38\(\pm\)0.01 | 41\(\pm\)1 | 95\(\pm\)8 | 92\(\pm\)3 |
Medium intensity nVNS | 6 | 7.38\(\pm\)0.01 | 39\(\pm\)1 | 102\(\pm\)6 | 95\(\pm\)6 |
High intensity nVNS | 6 | 7.41\(\pm\)0.01 | 36\(\pm\)2 | 104\(\pm\)2 | 90\(\pm\)3 |
Dose-response | Â | Â | Â | Â | Â |
Sham stimulation | 8 | 7.44\(\pm\)0.01 | 37\(\pm\)1 | 156\(\pm\)5 | 98±4 |
2\(\times\)2-min nVNS | 8 | 7.44\(\pm\)0.01 | 38\(\pm\)1 | 147\(\pm\)5 | 99\(\pm\)3 |
3\(\times\)2-min nVNS | 9 | 7.45\(\pm\)0.01 | 36\(\pm\)1 | 152\(\pm\)3 | 95\(\pm\)3 |
1\(\times\)6-min nVNS | 8 | 7.44\(\pm\)0.01 | 38\(\pm\)1 | 150\(\pm\)5 | 96\(\pm\)3 |
Chronic treatment | Â | Â | Â | Â | Â |
Daily nFNS | 6 | 7.42\(\pm\)0.01 | 39\(\pm\)1 | 134\(\pm\)5 | 107\(\pm\)4 |
Daily nVNS | 8 | 7.43\(\pm\)0.01 | 35\(\pm\)1* | 143\(\pm\)4 | 94\(\pm\)6 |