Fig. 4
From: Migraine-relevant sex-dependent activation of mouse meningeal afferents by TRPM3 agonists
No sex-difference in general nociceptive fibre excitability, Piezo1 activity and capsaicin sensitivity. (A) Histograms show the mean ± SEM number of nociceptive spikes in control conditions in males (n = 11) and females (n = 13) and the lack of a sex difference (p = 0.78, Mann–Whitney U test). (B) Histograms show the mean ± SEM number of nociceptive spikes during the 30-s active phase of 50 mM KCL application in males (n = 11) and females (n = 13) and the lack of a sex difference (p = 0.29, Mann–Whitney U test). (C) Histograms show the mean ± SEM number of nociceptive spikes during 10-min recordings after application of 5 μM Yoda1 in males (n = 11) and females (n = 13). (D) Histograms show the mean ± SEM number of nociceptive spikes during the 2-min active phase of 1 μM capsaicin application in males (n = 5) and females (n = 7). Notice the lack of a sex difference on firing when 5 μM Yoda (p = 0.94, Mann–Whitney U test) and 1 μM capsaicin (p = 0.53, Mann–Whitney U test) was applied