Fig. 4
From: Insulin sensitizes neural and vascular TRPV1 receptors in the trigeminovascular system
Changes in meningeal blood flow induced by topical application of capsaicin at high concentration. (A) Flowchart summarizing the experimental protocol. (B) Blood flow reducing effect of capsaicin (1 μM for 3 min) after preapplication of CGRP8–37 (10 μM for 5 min) or CGRP8–37 (10 μM for 5 min) followed by a mixture of CGRP8–37 and insulin (both at 10 μM for 10 min). The light grey bars indicate the effect of CGRP8–37 and the combination of CGRP8–37 and insulin, respectively. Coloured bars indicate the capsaicin-induced changes in blood flow. The number of measurements is indicated in the bars. *: statistically different from the basal flow. #: statistically different from the effect without insulin pretreatment