Fig. 2From: Insulin sensitizes neural and vascular TRPV1 receptors in the trigeminovascular systemChanges in meningeal blood flow induced by topical application of insulin. (A) Flowchart summarizing the experimental protocol. (B) Blood flow increasing effect of insulin (10 μM for 5 min) before and after CGRP8–37 or capsazepine (both at 10 μM for 5 min) applied topically to the dura mater. Effects of CGRP8–37 and capsazepine applications alone are also demonstrated. The number of measurements is indicated in the bars. *: statistically different from the basal flow. #: statistically different from the effect without pretreatmentBack to article page