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Fig. 2 | The Journal of Headache and Pain

Fig. 2

From: Insulin sensitizes neural and vascular TRPV1 receptors in the trigeminovascular system

Fig. 2

Changes in meningeal blood flow induced by topical application of insulin. (A) Flowchart summarizing the experimental protocol. (B) Blood flow increasing effect of insulin (10 μM for 5 min) before and after CGRP8–37 or capsazepine (both at 10 μM for 5 min) applied topically to the dura mater. Effects of CGRP8–37 and capsazepine applications alone are also demonstrated. The number of measurements is indicated in the bars. *: statistically different from the basal flow. #: statistically different from the effect without pretreatment

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