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Fig. 1 | The Journal of Headache and Pain

Fig. 1

From: Insulin sensitizes neural and vascular TRPV1 receptors in the trigeminovascular system

Fig. 1

Change in CGRP release in the hemisected skull preparation. (A) CGRP concentrations measured in control rats after topical applications of insulin at 1 μM and 10 μM and in capsaicin desensitized animals at 10 μM. (B) CGRP releasing effect of insulin at 10 μM before and after insulin receptor antagonist (BMS-754807 at 100 nM). (C) CGRP releasing effect of insulin at 10 μM before and after TRPV1 receptor antagonist capsazepine (10 μM). (D) CGRP releasing effect of capsaicin at 10 nM before and after the application of insulin (10 μM). Light grey bars indicate the basal release, coloured bars indicate the stimulated CGRP release in the same preparation. The number of measurements is indicated in the bars. *: statistically different from the basal CGRP release. #: statistically different from the control or the effect without pretreatment

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