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Fig. 8 | The Journal of Headache and Pain

Fig. 8

From: IL-17 crosses the blood–brain barrier to trigger neuroinflammation: a novel mechanism in nitroglycerin-induced chronic migraine

Fig. 8

NTG administration increased BBB permeability. (A) NTG enhanced the transportation function of BBB. (C-F) The expression of RAGE, LRP1, AQP4 and MFSD2A in the TNC of rats with NTG-induced migraine. (B) NTG altered the structure of BBB. (G-I) The expression of ZO-1, Occludin and VE-cadherin-2 in the TNC of rats with NTG-induced migraine. (J-L) NTG increased the permeability of peripheral dye. After Cy5.5 circulation for 30 min, NTG was subcutaneously injected. A live imaging system recorded the fluorescence signals at 695 nm for 4 h at 5 min intervals. Statistical analysis was performed using one-way ANOVA, n = 3, *p < 0.05 compared to the control group

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