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Fig. 3 | The Journal of Headache and Pain

Fig. 3

From: Cortical spreading depression induces propagating activation of the thalamus ventral posteromedial nucleus in awake mice

Fig. 3

Spatiotemporal evolution of CSD-related responses from the VPM in a single trial. A Fluorescence response evoked by one CSD. Eight ROIs were selected to analyse their temporal-spatial characteristics. The upper row showed the raw fluorescence intensity, and the lower row showed the relative fluorescence change. The response first arisesd at the upper left and ends at the lower right of the imaging field. B The fluorescence intensity changes of the VPM and the simultaneous DC shift in the cortex. Dashed line indicated the timing for adding KCl. The purple shaded areas indicated the movement of the mouse. The motion-related fluorescence change was relatively small compared to that of CSD. C The fluorescence intensity changes of the eight ROIs. The ROI located more posterior- lateral reached the maximum fluorescence intensity earlier than the other ROIs

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