| History of migraine | |
---|---|---|
No (n = 87,960) | Yes (n = 21,990) | |
Ischemic stroke | ||
 Number of events | 1383 | 406 |
 Follow-up in person-years | 342,211 | 86,726 |
 Incidence rate (95% CI)a | 4.0 (3.8, 4.3) | 4.7 (4.2, 5.1) |
 Hazard ratio (95% CI) | ||
  Model 1 | 1 (ref) | 1.16 (1.03, 1.29) |
  Model 2 | 1 (ref) | 1.21 (1.08, 1.35) |
  Model 3 | 1 (ref) | 1.21 (1.08, 1.36) |
  Model 4 | 1 (ref) | 1.20 (1.07, 1.35) |
Coronary heart diseaseb | ||
 Number of events | 2832 | 720 |
 Follow-up in person-years | 338,452 | 85,866 |
 Incidence rate (95% CI)a | 8.4 (8.1, 8.7) | 8.4 (7.8, 9.0) |
 Hazard ratio (95% CI) | ||
  Model 1 | 1 (ref) | 1.00 (0.92, 1.09) |
  Model 2 | 1 (ref) | 1.01 (0.93, 1.09) |
  Model 3 | 1 (ref) | 1.01 (0.93, 1.10) |
  Model 4 | 1 (ref) | 1.02 (0.93, 1.11) |
Composite CVD events | ||
 Number of events | 4050 | 1084 |
 Follow-up in person-years | 335,734 | 84,942 |
 Incidence rate (95% CI)a | 12.1 (11.7, 12.4) | 12.8 (12.0, 13.5) |
 Hazard ratio (95% CI) | ||
  Model 1 | 1 (ref) | 1.06 (0.99, 1.13) |
  Model 2 | 1 (ref) | 1.08 (1.01, 1.15) |
  Model 3 | 1 (ref) | 1.08 (1.01, 1.16) |
  Model 4 | 1 (ref) | 1.08 (1.01, 1.16) |