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Fig. 1 | The Journal of Headache and Pain

Fig. 1

From: Understanding the link between obesity and headache- with focus on migraine and idiopathic intracranial hypertension

Fig. 1

The effects of obesity on headache and the trigeminovascular system. Obesity has been demonstrated to affect several aspects associated with headache. Obesity alters headache-like behavior including increasing photophobia and thermal allodynia. This is associated with a series of physiological differences including increased cortical spreading depression (CSD) frequency. The trigemino-vascular system (TGVS) also is altered with obesity where the release of calcitonin gene related peptide (CGRP) from dura middle meningeal artery (MMA) calibre (Ø) display a greater response to noxious stimuli. The molecular underpinnings of these are unknown and it is unknown how obesity related systemic inflammation and intracranial pressure (ICP) alter the TGVS or headache in general

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The Journal of Headache and Pain

ISSN: 1129-2377

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