Enhanced functional connectivity between habenula and salience network in medication-overuse headache complicating chronic migraine positions it within the addiction disorders: an ICA-based resting-state fMRI study

Table 2 Altered resting-state functional connectivity of the habenula and the SN^a amongst MOH + CM^b, EM^c and HC^d, and between MOH + CM subgroups with or without depression

Brain region	Number of voxels	Cluster size, mm³	MNI coordinates, mm			F score (max)	p value
Brain region	Number of voxels	Cluster size, mm³	x	y	z	F score (max)	p value
MOH + CM VS HC
R^e habenula	7	56	4	-25	2	3.38	< 0.001
L^f habenula	7	56	-3	-25	2	3.09	0.002
MOH + CM VS EM
R habenula	7	56	4	-23	2	2.73	0.006
L habenula	7	56	-3	-23	2	3.03	0.002
EM VS HC
R habenula	0	0	3	-25	2	1.76	0.079
L habenula	0	0	4	-24	2	1.51	0.132
MOH + CM ^depression VS MOH + CM ^{without depression}
R habenula	0	0	5	-24	2	0.85*	0.475
L habenula	0	0	4	-24	2	1.99*	0.077

^a SN, salience network; ^b MOH + CM, medication-overuse headache + chronic migraine; ^c EM, episodic migraine; ^d HC, healthy controls; ^e R, right; ^f L, left
*T score from two-sample t test

ISSN: 1129-2377