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Table 2 Altered resting-state functional connectivity of the habenula and the SNa amongst MOH + CMb, EMc and HCd, and between MOH + CM subgroups with or without depression

From: Enhanced functional connectivity between habenula and salience network in medication-overuse headache complicating chronic migraine positions it within the addiction disorders: an ICA-based resting-state fMRI study

Brain region Number of voxels Cluster size, mm3 MNI coordinates, mm F score (max) p value
x y z
MOH + CM VS HC
  Re habenula 7 56 4 -25 2 3.38 < 0.001
  Lf habenula 7 56 -3 -25 2 3.09 0.002
MOH + CM VS EM
  R habenula 7 56 4 -23 2 2.73 0.006
   L habenula 7 56 -3 -23 2 3.03 0.002
EM VS HC
  R habenula 0 0 3 -25 2 1.76 0.079
   L habenula 0 0 4 -24 2 1.51 0.132
MOH + CM depression VS MOH + CM without depression
  R habenula 0 0 5 -24 2 0.85* 0.475
  L habenula 0 0 4 -24 2 1.99* 0.077
  1. a SN, salience network; b MOH + CM, medication-overuse headache + chronic migraine; c EM, episodic migraine; d HC, healthy controls; e R, right; f L, left
  2. *T score from two-sample t test