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Table 1 Demographic and clinical data for all participants

From: Enhanced functional connectivity between habenula and salience network in medication-overuse headache complicating chronic migraine positions it within the addiction disorders: an ICA-based resting-state fMRI study

Clinical details

MOH + CMa patients

EMb patients

Healthy controls

p value

Age, years

46.6 ± 10.3

38.0 ± 14.4

40.8 ± 9.7

0.078

Sex

3Mc, 14Fd

4 M, 14 F

11 M, 19 F

0.298

Headache history, years

22.8 ± 8.9

10.8 ± 6.9

 N/Ae

< 0.001

Medication-overuse duration, years

7.3 ± 6.4

 N/A

N/A

N/A

Headache location

Right; Left; Bilateral

2 (11.8 %); 2 (11.8 %); 13 (76.5 %)

2 (11.1 %); 7 (38.9 %); 9 (50 %)

N/A; N/A; N/A

N/A; N/A; N/A

VASf

8.4 ± 1.4

8.0 ± 1.4

 N/A

0.465

PHQ9

8.7 ± 6.7

2.4 ± 4.8

2.5 ± 2.2

< 0.05h

GAD-7i

2.9 ± 3.9

1.6 ± 3.6

2.6 ± 2.1

0.729

  1. a MOH + CM, medication-overuse headache + chronic migraine; b EM, episodic migraine; c M, male; d F, female; e NA, not applicable; f VAS, visual analog scale; g PHQ-9, Patient Health Questionnaire 9 Depression Scale; h Post-hoc analysis using LSD resulted significant difference between MOH + CM and EM with p value of 0.018, MOH + CM with HC with p value of 0.002. Meanwhile there was no significant difference between EM and HC with p value of 0.978; i GAD-7, Generalized Anxiety Disorder Assessment 7-item Scale. Data are mean ± standard deviation