Identifying genetic variants for age of migraine onset in a Han Chinese population in Taiwan

Table 3 Association of onset age of the all-migraine cohort in the subgroups with or without aura

Group	SNP	Position (GRCh38.p12)	MAF	TWB	Gene	Type	Variant Change	P-value	β (Beta)
All migraine cohort	rs181024055	chr10:113595726	0.022	0.003	NRAP	exonic	C > T	4.89 × 10^-8*	20.41
Aura	rs77630941	chr7:102217020	0.020	0.032	CUX1	intronic	T > C	6.66 × 10^-10*	28.37
	rs146778855	chr5:20412078	0.020	0.014	CDH18	intronic	C > T	1.21 × 10^-8*	20.63
	rs117608715	chr16:67172270	0.010	0.030	NOL3	intronic	C > T	1.78 × 10^-8*	22.74
	rs150592309	chr10:133346685	0.00	0.024	PRAP1	upstream	G > A	8.88 × 10^-8	21.72
Without aura	rs181024055	chr10:113595726	0.022	0.003	NRAP	exonic	C > T	4.89 × 10^-8*	23.74

A quantitative association study was performed on the all-migraine cohort of AoM and was, then, grouped based on the presence and absence of aura. Significant variants with P < 5 × 10^-8 are listed with the beta value of the regression coefficient
CUX1 cut like homeobox 1, CDH18 cadherin 18, NOL3 nucleolar protein 3, PRAP1 proline rich acidic protein 1, NRAP nebulin related anchoring protein; minor allele frequency of the East Asian group in dbSNP, TWB Minor allele frequency in the Taiwan Biobank
^*is the criteria whose P-value < 5 × 10⁻⁸

ISSN: 1129-2377