Identifying genetic variants for age of migraine onset in a Han Chinese population in Taiwan

Table 2 Associations with onset age of migraine

								Risk allele frequency
Age of Onset	SNP	Position (GRCh38.p12)	MAF	TWB	Gene	Type	Variant Change	≤ 12	> 12	P-value	OR
≤ 12 vs. >12	rs146094041	chr1:217,092,941	0.01	0.02	ESRRG	intronic/Del	CAA > -	6.78 %	0.38 %	3.40 × 10^− 9*	0.053 [0.014,0.20]

Patients with migraine were grouped based on the age of onset and were compared using PLINK
ESRRG estrogen-related receptor gamma, MAF minor allele frequency of East Asian group in dbSNP, TWB minor allele frequency in the Taiwan Biobank
Significant variants with P < 5× 10^− 8 are listed with the allele frequency and odds ratio (OR) with 95 % confident interval for the phenotype association study on the onset of migraine before or after 12 years of age
* is the criteria whose P-value was <\(5\times {10}^{-8}\)

ISSN: 1129-2377