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Fig. 9 | The Journal of Headache and Pain

Fig. 9

From: Repeated oxytocin prevents central sensitization by regulating synaptic plasticity via oxytocin receptor in a chronic migraine mouse model

Fig. 9

Effect of OT on the AC1/PKA/pCREB pathway. A, B and C WB results showed that the protein levels of AC1 (A), PKA (B), and pCREB (C) were significantly elevated in the NTG + vehicle group compared with the sham group. The expression levels of these three proteins after OT treatment were reduced, while L368,899 prevented the effect of OT. D There was no significant difference in CREB expression among the four groups. One-way ANOVA with Dunnett’s post hoc test, n = 6/group; **p < 0.01, ***p < 0.001 vs. the sham group; ##p < 0.01, ###p < 0.001 vs. the NTG + vehicle group; &p < 0.05 vs. the NTG + OT group

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