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Fig. 1 | The Journal of Headache and Pain

Fig. 1

From: Repeated oxytocin prevents central sensitization by regulating synaptic plasticity via oxytocin receptor in a chronic migraine mouse model

Fig. 1

Repeated NTG administration induced basal hyperalgesia and upregulated CGRP and c-fos protein expression. A Timeline for the first experiment, D:day. B, C and D The basal mechanical pain threshold of the hind paw (B) periorbital area (C) and the thermal pain threshold of the hind paw (D) were significantly decreased in the NTG group, compared with the sham group beginning on the third day. Two-way ANOVA with the Bonferroni post hoc test, n = 6/group, **p < 0.01, ***p < 0.001. E, F, G The protein expression of CGRP and c-fos was assessed by WB assay and was markedly higher in the NTG group than in the sham group. Two-tailed Student’s t-test, n = 6/group, **p < 0.01, ***p < 0.001

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