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Table 3 Functional enrichment results of PBMC RNA-seq data of the ictal vs. interictal comparison. DE list enrichment: overrepresentation of functional terms in the differentially expressed gene list. Ranked list enrichment: enrichment of genes associated with a certain pathway towards the top of the ranked whole data. GO: gene ontology, BP: biological process, CC: cellular component, MF molecular function. KEGG: Kyoto Encyclopedia of Genes and Genomes. Annotated: number of genes associated with the given term. R: Reactome database. Significant: number of statistically significant associated with the given term. Expected: expected number of genes associated with the given term in the DE gene list. Gene ratio: ratio of number of genes in the DE list that overlap with genes associated with the given term, and the number of genes in the DE list which overlap with genes associated with all terms in the Reactome database. Bg ratio: ratio of the number of genes associated with the given term, and the total number of genes associated with Reactome terms

From: Identification of disease- and headache-specific mediators and pathways in migraine using blood transcriptomic and metabolomic analysis

Ictal vs. interictal

ID

DE list enrichment

Annotated

Significant

Expected

p-value

GO:1902305 BP

regulation of sodium ion transmembrane transport

55

4

0.39

2.60E-14

GO:0070382 CC

exocytic vesicle

175

6

1.3

0.0019

GO:0005179

hormone activity

61

3

0.43

0.00924

KEGG 4742

Taste transduction

35

2

0.219161

0.019843

 

Ranked list enrichment

Annotated

  

p-value

GO:0005746 CC

mitochondrial respiratory chain

82

  

2.60E-14

GO:0005125 MF

cytokine activity

149

  

0.000001

GO:0005179 MF

hormone activity

61

  

6.95E-05

GO:0030594 MF

neurotransmitter receptor activity

57

  

0.000107

GO:0004984 MF

olfactory receptor activity

44

  

0.000433

KEGG 4080

Neuroactive ligand-receptor interaction

157

  

9.04E-05

KEGG 190

Oxidative phosphorylation

121

  

0.000845

KEGG 140

Steroid hormone biosynthesis

36

  

0.00112