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Fig. 5 | The Journal of Headache and Pain

Fig. 5

From: CGRP induces migraine-like symptoms in mice during both the active and inactive phases

Fig. 5

Peripheral CGRP increases the time resting in the dark during both the active and inactive phases. In all panels, grey areas represent the active phase of the animals when lights of the facility were turned off (night). Percent time resting in the dark and light zones by CD1 mice during sequential exposures to the light/dark chamber at 25,000 lx (same experiments as in Fig. 2). On test days, animals were tested 30 min after injection of vehicle (PBS, i.p.) or CGRP (0.1 mg/kg i.p.). A Resting time in dark zone during the same experiment represented in Fig. 2A. Two-way (factors: time x treatment) ANOVA, Sidak’s multiple comparison test *p < 0.05, **p < 0.01 and ***p < 0.001 compared to corresponding time point in vehicle group. B Resting time in light zone during the same experiment represented in Fig. 2A. Two-way (factors: time x treatment) ANOVA (treatment factor p = 0.2743 for first test and p = 0.8969 for second test). C Resting time in dark zone during the same experiment represented in Fig. 2C. Two-way (factors: time x treatment) ANOVA, Sidak’s multiple comparison test *p < 0.05, **p < 0.01 and ***p < 0.001 compared to corresponding time point in vehicle group. D Resting time in light zone during the same experiment represented in Fig. 2C. Two-way (factors: time x treatment) ANOVA (ns)

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