Table 2 Effect of vlPAG optogenetic activation in mechanical and thermal pain sensitivity on trigeminal facial area
Laser off | Laser on | |
|---|---|---|
Air puff threshold (psi) | ||
TN/ChR2 | 5.33 ± 0.47 | 18.33 ± 1.25**** |
TN/EYFP | 6.67 ± 2.05 | 7.11 ± 1.63**** |
Sham/ChR2 | 21.11 ± 1.25 | 20.13 ± 2.32 |
Sham/EYFP | 20.21 ± 3.10 | 21.23 ± 1.10 |
Cold hyperalgesia (No. of responses) | ||
TN/ChR2 | 27 ± 1.25 | 10 ± 0.47**** |
TN/EYFP | 28 ± 1.63 | 26 ± 2.05**** |
Sham/ChR2 | 10 ± 2.0 | 9 ± 1.50 |
Sham/EYFP | 8.5 ± 2.5 | 9.5 ± 1.32 |