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Fig. 4 | The Journal of Headache and Pain

Fig. 4

From: Activation of CamKIIα expressing neurons on ventrolateral periaqueductal gray improves behavioral hypersensitivity and thalamic discharge in a trigeminal neuralgia rat model

Fig. 4

Electrophysiological findings from VPM thalamus under optogenetic stimulation of vlPAG. a Mean firing rates in VPM neurons in TN animals against sham animals (****, p < 0.0001, significant variation defined using unpaired t-tests). b i. Schematic diagram showing recording area and optic stimulation area. ii. Representative spike traces (above) and rate histogram (below) obtained from a TN/ChR2 rats in blue laser stimulation on and off conditions. c Representative raster traces recorded from VPM thalamus of TN and sham animals. d Spontaneous(i) and evoked (ii) in vivo burst recordings obtained from the VPM thalamus during different light conditions. e Spontaneous and evoked mean firing rate (expressed in spikes per second) from TN/ChR2 and TN/EYFP rats in different laser conditions. f Representative firing frequencies (expressed as impulses per second) observed in animal groups (i. TN/ChR2, ii TN/EYFP, iii. Sham/ChR2, iv. sham/EYFP) through various light frame. ****, p < 0.0001, significant difference determined via two-way analysis of variance (ANOVA)

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