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Fig. 3 | The Journal of Headache and Pain

Fig. 3

From: Activation of CamKIIα expressing neurons on ventrolateral periaqueductal gray improves behavioral hypersensitivity and thalamic discharge in a trigeminal neuralgia rat model

Fig. 3

Pain behavioral alteration observed in TN and sham groups. a Experimental design for pain behavior test and cannula implantation in animal models (b) Diagram showing area coordinates for virus injection and optic stimulation. c Air-puff test results for the ipsilateral and contralateral trigeminal facial area. d Cold hyperalgesia results for the ipsilateral facial area following treatment with acetone drops. e Air-puff test scores for the ipsilateral trigeminal facial region under optic stimulation. f Number of immediate responses at the ipsilateral facial area following treatment with acetone drops under optogenetic stimulation in vlPAG. ****, p < 0.0001, significant difference determined via two-way analysis of variance (ANOVA)

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