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Fig. 5 | The Journal of Headache and Pain

Fig. 5

From: P2X3 receptor upregulation in trigeminal ganglion neurons through TNFα production in macrophages contributes to trigeminal neuropathic pain in rats

Fig. 5

Involvement of TNFR2 signaling in the enhanced P2X3R expression in TG neurons on day 7 following TNC. a Photomicrograph of FG-labeled P2X3-IR and TNFR2-IR TG neurons following TNC with intra-TG etanercept or vehicle administration. Arrows indicate FG-labeled P2X3-IR and TNFR2-IR TG neurons. Scale bar: 100 μm. b Changes in the mean percentage of FG-labeled P2X3-IR and TNFR2-IR TG neurons on day 7 following TNC with intra-TG etanercept or vehicle administration. * p < 0.05 vs. vehicle. (n = 6 in each, student’s t-test)

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