Fig. 5From: P2X3 receptor upregulation in trigeminal ganglion neurons through TNFα production in macrophages contributes to trigeminal neuropathic pain in ratsInvolvement of TNFR2 signaling in the enhanced P2X3R expression in TG neurons on day 7 following TNC. a Photomicrograph of FG-labeled P2X3-IR and TNFR2-IR TG neurons following TNC with intra-TG etanercept or vehicle administration. Arrows indicate FG-labeled P2X3-IR and TNFR2-IR TG neurons. Scale bar: 100 μm. b Changes in the mean percentage of FG-labeled P2X3-IR and TNFR2-IR TG neurons on day 7 following TNC with intra-TG etanercept or vehicle administration. * p < 0.05 vs. vehicle. (n = 6 in each, student’s t-test)Back to article page