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Fig. 3 | The Journal of Headache and Pain

Fig. 3

From: P2X3 receptor upregulation in trigeminal ganglion neurons through TNFα production in macrophages contributes to trigeminal neuropathic pain in rats

Fig. 3

TNFR2 expression in TG neurons innervating the whisker pad skin on day 7 following TNC or sham treatment. a Photomicrographs of FG-labeled TNFR2-IR cells in the TG on day 7 following TNC or sham treatment. Arrows indicate FG-labeled TNFR2-IR cells. Scale bar: 100 μm. b Mean percentage of FG-labeled TNFR2-IR cells in the TG on day 7 following TNC or sham treatment. (n = 6 in each). c Effect of intra-TG etanercept or vehicle administration on day 4 on orofacial mechanical hypersensitivity following TNC or sham treatment. Data are presented as median, interquartile range (25–75 %), and maximum and minimum values. * p < 0.05. (n = 4–6; Kruskal-Wallis followed by Dunn’s multiple comparisons test)

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The Journal of Headache and Pain

ISSN: 1129-2377

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