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Fig. 2 | The Journal of Headache and Pain

Fig. 2

From: P2X3 receptor upregulation in trigeminal ganglion neurons through TNFα production in macrophages contributes to trigeminal neuropathic pain in rats

Fig. 2

TNFα and Iba1 expression in the TG on day 7 following TNC or sham procedure. a Photomicrographs of Iba1-IR cells in the depressed trigeminal root on day 7 following TNC or sham treatment. The right image shows an enlarged image surrounded by a white frame. Arrows indicate Iba1-IR cells in the depressed trigeminal root. Mean number of Iba1-positive cells in the TG section on day 7 following the TNC or sham procedure. * p < 0.05 vs. sham. (n = 6 in each, student’s t-test). b Photomicrographs of TNFα-IR and Iba1-IR cells in the TG on day 7 following TNC or sham treatment. Arrows indicate TNFα-IR and Iba1-IR cells in the TG. Scale bar: 100 μm. c Relative amount of TNFα protein in the TG in naive rats or on day 7 following the TNC or sham procedure. ** p < 0.01 vs. sham. (n = 6 in each, F = 9.57, one-way ANOVA with Tukey’s multiple comparison test)

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