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Table 2 Intragroup monthly basis analysis of Migraine attack, Headache severity, Headache duration and Painkiller number (A: Sodium Valproate; B: Sodium Valproate +Magnesium; C: Magnesium); *P values≤0.05 were considered statistically significant

From: Comparative study of magnesium, sodium valproate, and concurrent magnesium-sodium valproate therapy in the prevention of migraine headaches: a randomized controlled double-blind trial

Group

A

B

C

A vs B

A vs C

B vs C

p- value

Mean Difference

95% CI

p- value

Mean Difference

95% CI

p- value

Mean Difference

95% CI

Migraine attack (n), mean ± SD

 baseline

6.65 ± 1.65

6.89 ± 1.52

7.06 ± 1.54

0.621

− 0.24

− 0.85 to 0.37

0.248

− 0.41

−1.02 to 0.20

0.797

− 0.17

− 0.80 to 0.46

 After 1 month

4.09 ± 0.99

4.04 ± 0.93

5.49 ± 1.45

0.972

0.05

− 0.40 to 0.48

<  0.001

− 1.40

− 1.84 to − 0.96

< 0.001

−1.45

− 1.90 to 0.99

 After 2 month

2.83 ± 0.73

2.47 ± 0.71

4.21 ± 0.08

0.029

0.36

0.03 to 0.69

<  0.001

− 1.38

− 1.71 to − 1.06

<  0.001

− 1.74

−2.08 to − 1.40

 After 3 month

1.60 ± 0.76

1.40 ± 0.75

3.91 ± 0.86

0.525

0.20

− 0.17 to 0.45

< 0.001

−2.31

− 2.62 to − 2.01

<  0.001

−2.51

− 2.77 to − 2.14

Headache severity, mean ± SD

 baseline

5.33 ± 0.67

5.27 ± 0.79

5.16 ± 1.02

0.885

0.06

− 0.25 to 0.38

0.424

0.17

− 0.15 to 0.49

0.732

0.11

− 0.22 to 0.43

 After 1 month

3.68 ± 0.81

3.69 ± 0.73

3.93 ± 1.24

0.999

− 0.01

−0.37 to 0.35

0.243

−0.25

− 0.61 to 0.11

0.287

− 0.24

−0.62 to 0.13

 After 2 month

2.51 ± 0.68

2.16 ± 0.67

3.32 ± 0.78

0.01

0.35

− 0.06 to 0.61

<  0.001

− 0.81

− 1.08 to − 0.54

<  0.001

− 1.16

− 1.44 to 0.87

 After 3 month

1.71 ± 0.55

1.26 ± 0.59

2.41 ± 1.15

0.002

0.45

− 0.13 to 0.75

< 0.001

−0.70

− 1.00 to − 0.39

<  0.001

− 1.15

− 1.46 to − 0.82

Headache duration (h), mean ± SD

 baseline

11.56 ± 3.53

11.96 ± 1.73

10.99 ± 2.49

0.649

− 0.40

− 1.45 to 0.66

0.403

0.57

− 0.48 to 1.63

0.093

0.97

−0.12 to 2.07

 After 1 month

10.39 ± 2.87

9.95 ± 1.80

10.64 ± 1.96

0.481

0.44

− 0.45 to 1.31

0.779

− 0.25

− 1.13 to 0.63

0.185

− 0.69

− 1.60 to 0.23

 After 2 month

8.19 ± 2.76

7.22 ± 1.66

9.30 ± 1.84

0.019

0.97

0.12 to 1.80

0.006

−1.11

− 1.94 to − 0.26

<  0.001

− 2.08

− 2.94 to − 1.20

 After 3 month

7.06 ± 2.53

6.08 ± 1.75

8.15 ± 1.83

0.013

0.98

0.17 to 1.77

0.004

− 1.09

− 1.90 to − 0.29

<  0.001

−2.07

− 2.90 to − 1.23

Painkiller (n),mean ± SD

 baseline

6.45 ± 0.95

6.27 ± 0.94

6.05 ± 1.48

0.601

0.18

−0.26 to 0.62

0.083

0.40

−0.04 to 0.84

0.489

0.22

−0.24 to 0.68

 After 1 month

4.15 ± 0.93

4.07 ± 0.73

4.55 ± 1.13

0.871

0.08

− 0.29 to 0.44

0.031

− 0.40

− 0.76 to − 0.03

0.010

−0.48

− 0.85 to − 0.09

 After 2 month

3.11 ± 0.68

2.21 ± 0.75

3.46 ± 0.89

<  0.001

0.90

0.60 to 1.19

0.017

− 0.35

−0.64 to − 0.05

< 0.001

− 1.25

− 1.55 to − 0.93

 After 3 month

1.72 ± 0.58

1.26 ± 0.59

2.37 ± 0.78

< 0.001

0.46

0.20 to 0.71

< 0.001

−0.65

− 0.89 to − 0.39

<  0.001

− 1.11

−1.36 to − 0.84