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Table 2 Intragroup monthly basis analysis of Migraine attack, Headache severity, Headache duration and Painkiller number (A: Sodium Valproate; B: Sodium Valproate +Magnesium; C: Magnesium); *P values≤0.05 were considered statistically significant

From: Comparative study of magnesium, sodium valproate, and concurrent magnesium-sodium valproate therapy in the prevention of migraine headaches: a randomized controlled double-blind trial

Group A B C A vs B A vs C B vs C
p- value Mean Difference 95% CI p- value Mean Difference 95% CI p- value Mean Difference 95% CI
Migraine attack (n), mean ± SD
 baseline 6.65 ± 1.65 6.89 ± 1.52 7.06 ± 1.54 0.621 − 0.24 − 0.85 to 0.37 0.248 − 0.41 −1.02 to 0.20 0.797 − 0.17 − 0.80 to 0.46
 After 1 month 4.09 ± 0.99 4.04 ± 0.93 5.49 ± 1.45 0.972 0.05 − 0.40 to 0.48 <  0.001 − 1.40 − 1.84 to − 0.96 < 0.001 −1.45 − 1.90 to 0.99
 After 2 month 2.83 ± 0.73 2.47 ± 0.71 4.21 ± 0.08 0.029 0.36 0.03 to 0.69 <  0.001 − 1.38 − 1.71 to − 1.06 <  0.001 − 1.74 −2.08 to − 1.40
 After 3 month 1.60 ± 0.76 1.40 ± 0.75 3.91 ± 0.86 0.525 0.20 − 0.17 to 0.45 < 0.001 −2.31 − 2.62 to − 2.01 <  0.001 −2.51 − 2.77 to − 2.14
Headache severity, mean ± SD
 baseline 5.33 ± 0.67 5.27 ± 0.79 5.16 ± 1.02 0.885 0.06 − 0.25 to 0.38 0.424 0.17 − 0.15 to 0.49 0.732 0.11 − 0.22 to 0.43
 After 1 month 3.68 ± 0.81 3.69 ± 0.73 3.93 ± 1.24 0.999 − 0.01 −0.37 to 0.35 0.243 −0.25 − 0.61 to 0.11 0.287 − 0.24 −0.62 to 0.13
 After 2 month 2.51 ± 0.68 2.16 ± 0.67 3.32 ± 0.78 0.01 0.35 − 0.06 to 0.61 <  0.001 − 0.81 − 1.08 to − 0.54 <  0.001 − 1.16 − 1.44 to 0.87
 After 3 month 1.71 ± 0.55 1.26 ± 0.59 2.41 ± 1.15 0.002 0.45 − 0.13 to 0.75 < 0.001 −0.70 − 1.00 to − 0.39 <  0.001 − 1.15 − 1.46 to − 0.82
Headache duration (h), mean ± SD
 baseline 11.56 ± 3.53 11.96 ± 1.73 10.99 ± 2.49 0.649 − 0.40 − 1.45 to 0.66 0.403 0.57 − 0.48 to 1.63 0.093 0.97 −0.12 to 2.07
 After 1 month 10.39 ± 2.87 9.95 ± 1.80 10.64 ± 1.96 0.481 0.44 − 0.45 to 1.31 0.779 − 0.25 − 1.13 to 0.63 0.185 − 0.69 − 1.60 to 0.23
 After 2 month 8.19 ± 2.76 7.22 ± 1.66 9.30 ± 1.84 0.019 0.97 0.12 to 1.80 0.006 −1.11 − 1.94 to − 0.26 <  0.001 − 2.08 − 2.94 to − 1.20
 After 3 month 7.06 ± 2.53 6.08 ± 1.75 8.15 ± 1.83 0.013 0.98 0.17 to 1.77 0.004 − 1.09 − 1.90 to − 0.29 <  0.001 −2.07 − 2.90 to − 1.23
Painkiller (n),mean ± SD
 baseline 6.45 ± 0.95 6.27 ± 0.94 6.05 ± 1.48 0.601 0.18 −0.26 to 0.62 0.083 0.40 −0.04 to 0.84 0.489 0.22 −0.24 to 0.68
 After 1 month 4.15 ± 0.93 4.07 ± 0.73 4.55 ± 1.13 0.871 0.08 − 0.29 to 0.44 0.031 − 0.40 − 0.76 to − 0.03 0.010 −0.48 − 0.85 to − 0.09
 After 2 month 3.11 ± 0.68 2.21 ± 0.75 3.46 ± 0.89 <  0.001 0.90 0.60 to 1.19 0.017 − 0.35 −0.64 to − 0.05 < 0.001 − 1.25 − 1.55 to − 0.93
 After 3 month 1.72 ± 0.58 1.26 ± 0.59 2.37 ± 0.78 < 0.001 0.46 0.20 to 0.71 < 0.001 −0.65 − 0.89 to − 0.39 <  0.001 − 1.11 −1.36 to − 0.84
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