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Fig. 3 | The Journal of Headache and Pain

Fig. 3

From: Effect of dural inflammatory soup application on activation and sensitization markers in the caudal trigeminal nucleus of the rat and the modulatory effects of sumatriptan and kynurenic acid

Fig. 3

Statistical analysis of CGRP staining 2.5 and 4 h after IS treatment The quantitative analysis shows that in the IS group the area covered by fibers showing CGRP positivity is significantly higher than in the control group in both timepoints. a 2.5 h after IS treatment, sumatriptan was able to attenuate this effect in the V/1 area. b Similar to sumatriptan kynurenic acid weakened the effect of IS in the V/1 area. c 4 h after IS treatment, sumatriptan was able to mitigate this effect in the and V/1 area. d Kynurenic acid decreased the effect of IS in the V/1 area. *p < 0.05; **p < 0.01, ***p < 0.001 * means SIF-IS differences, + means IS-SUMA/KYNA. SIF: synthetic interstitial fluid, IS: inflammatory soup, SUMASIF: sumatriptan + synthetic interstitial fluid, SUMAIS: sumatriptan + inflammatory soup, KYNSIF: kynurenic acid + synthetic interstitial fluid, KYNIS: kynurenic acid + inflammatory soup

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The Journal of Headache and Pain

ISSN: 1129-2377

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