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Fig. 1 | The Journal of Headache and Pain

Fig. 1

From: Effect of dural inflammatory soup application on activation and sensitization markers in the caudal trigeminal nucleus of the rat and the modulatory effects of sumatriptan and kynurenic acid

Fig. 1

CGRP immunoreactivity 2.5 h after IS treatment Representative photomicrographs of the CGRP expression in the trigemino-cervical segments after 2.5 h. a – SIF, b – IS, c – SUMASIF, d – SUMAIS, e – KYNSIF, f – KYNIS. In the IS group, the CGRP staining was stronger than in the placebo group. Sumatriptan and kynurenic acid were able to attenuate this effect. SIF: synthetic interstitial fluid, IS: inflammatory soup, SUMASIF: sumatriptan + synthetic interstitial fluid, SUMAIS: sumatriptan + inflammatory soup, KYNSIF: kynurenic acid + synthetic interstitial fluid, KYNIS: kynurenic acid + inflammatory soup. Scale bars: 200 μm, 50 μm

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