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Table 9 Preventive medication against chronic migraine with recommended doses

From: Reference programme: diagnosis and treatment of headache disorders and facial pain. Danish Headache Society, 3rd edition, 2020

Drug Daily dose
Beta-blockers:
 Metoprolol 50–200 mg
 Propranolol 40–240 mg
 Candesartancilexetil 16 (24–32) mg
 Topiramate 50–100 (200) mg
 Amitriptyline 10–100 mg
 Botulinum type a toxin 155–195 units i.m. Every 12 weeks
CGRP-antibodies:
 Erenumab 70–140 mg s.c. every 4 weeks
 Fremanezumab 225 mg s.c. every month or 675 mg s.c. every 3 months
 Galcanezumab Start dose 240 mg s.c. followed by 120 mg s.c. every month.
 Eptinezumab 100–300 mg i.v. every 3 months
  1. s.c. subcutaneous, i.m. intramuscular, iv. intravenous