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Table 9 Preventive medication against chronic migraine with recommended doses

From: Reference programme: diagnosis and treatment of headache disorders and facial pain. Danish Headache Society, 3rd edition, 2020

Drug Daily dose
 Metoprolol 50–200 mg
 Propranolol 40–240 mg
 Candesartancilexetil 16 (24–32) mg
 Topiramate 50–100 (200) mg
 Amitriptyline 10–100 mg
 Botulinum type a toxin 155–195 units i.m. Every 12 weeks
 Erenumab 70–140 mg s.c. every 4 weeks
 Fremanezumab 225 mg s.c. every month or 675 mg s.c. every 3 months
 Galcanezumab Start dose 240 mg s.c. followed by 120 mg s.c. every month.
 Eptinezumab 100–300 mg i.v. every 3 months
  1. s.c. subcutaneous, i.m. intramuscular, iv. intravenous