Table 9 Preventive medication against chronic migraine with recommended doses

 Metoprolol

50–200 mg

 Propranolol

40–240 mg

 Candesartancilexetil

16 (24–32) mg

 Topiramate

50–100 (200) mg

 Amitriptyline

10–100 mg

 Botulinum type a toxin

155–195 units i.m. Every 12 weeks

 Erenumab

70–140 mg s.c. every 4 weeks

 Fremanezumab

225 mg s.c. every month or 675 mg s.c. every 3 months

 Galcanezumab

Start dose 240 mg s.c. followed by 120 mg s.c. every month.

 Eptinezumab

100–300 mg i.v. every 3 months