Fig. 1
From: Familial hemiplegic migraine type 2 due to a novel missense mutation in ATP1A2
Pedigree of the family and Sanger sequencing results. Genetic analysis was performed in 6 consanguineous patients of three generations, and revealed a dominant inheritance leading to the missense mutation L425H. Patient I-2 is deceased; she had complained of “limb paresthesias” followed by headache in her childhood. All the affected members were symptomatic for sporadic migraine with aura (II-2, III-1 and -2); II-2 and III-2 also had sporadic episodes of migraine without aura. The proband (III-2) was the only member with an episode of hemiplegic migraine, while the others only showed complex auras (visual, aphasic, sensory)