Table 1 Literatures on effects of probiotic supplementation on migraine headache
From: Gut-brain Axis and migraine headache: a comprehensive review
authors and year | Type of article | Sample size | Type of probiotics | Duration of treatment | Results |
|---|---|---|---|---|---|
De Roos N, Giezenaar C, Rovers J, et al. 2015 [89] | Clinical trial | 29 patients | 2 g/d of a probiotic food supplement (Ecologic(®)Barrier, 2.5 × 10(9) cfu/g) | 12 weeks | 1) number of migraine days/month decreased significantly 2) The MIDAS score improved 3) Headache Disability Inventory (HDI) did not change significantly |
de Roos N, van Hemert S, Rovers J, et al. 2017 [130] | Randomized control trial | 63 patients (probiotic (n = 31) placebo group (n = 32)) | multispecies probiotic (5 × 109 colony-forming units) or placebo daily | 12 weeks | No significant benefit from a multispecies probiotic compared to a placebo on the outcome parameters of migraine and intestinal integrity |
James Sensenig N, Jeffrey Marrongelle D and CCN MJ S. T. 2001 [126] | Clinical trial | 40 patients | Two nutritional formulations contained probiotics + minerals + vitamins + herbs | 3 months | 80% of the participants experienced significant improvements in quality of life and pain relief in more than half of the migraineurs |
Martami F, Togha M, Seifishahpar M, et al. 2019 [127] | randomized double-blind controlled trial | 40 episodic and 39 chronic migraine patients | 14-strain probiotic mixture or placebo | 10 weeks | Significant reduction in migraine attacks, migraine severity, and the number of abortive drugs in the probiotic group compare to the placebo group |